ABSTRACT
Giant ureteral calculus is a rare disease. It remains one of the few special situations where classical treatment of ureterolithotomy is done. We present a case of a 33-year-old female who presented with left flank pain radiating to groin. Investigations revealed two giant ureteral stones measuring 8 cm and 2cm. She was submitted to open surgery. There were no postoperative complications and the patient was discharged from hospital after 4 days. An IVU done 6 months after intervention showed adequate drainage of contrast in bilateral kidneys. This technical procedure could be performed by means of laparoscopy and be even less aggressive.
ABSTRACT
A rapid, stability-indicating reversed phase ultra-performance liquid chromatographic (RP-UPLC) method was developed for the determination of paliperidone palmitate (PP), in depot injectable dosage form. The chromatographic separation was achieved on an Acquity BEH C18 (50 mm × 2.1 mm, 1.7 μm) column, with a mobile phase consisting of ammonium acetate buffer, and acetonitrile at a ratio of 10:90 (v/v) and a flow rate of 0.6 mL/min. The eluted compound was monitored at a wavelength of 238 nm using a UV detector. The method described herein separated paliperidone palmitate from all other formulation components and two major known degradation products (N-Oxide and paliperidone) within a run time of 2.5 min. The method also generated linear results over a PP concentration range of 156 to 468 μg/mL. The stability indicating capability of the method was established by performing forced degradation experiments. The RP-UPLC method that was developed was validated according to the International Conference on Harmonization (ICH) guidelines. This method was successfully applied in the quantitative determination of PP in a stability study of paliperidone palmitate depot injection. The procedure described herein is simple, selective, and reliable for routine quality control analysis as well as stability testing.